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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEATR1
All Species:
20.91
Human Site:
S406
Identified Species:
35.38
UniProt:
Q9H583
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H583
NP_060542.4
2144
242370
S406
L
L
F
E
E
Y
I
S
Y
S
S
Q
E
E
M
Chimpanzee
Pan troglodytes
XP_001156974
2144
242420
S406
L
L
F
E
E
Y
I
S
Y
S
S
Q
E
E
M
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536334
2141
242568
S406
L
L
F
E
E
Y
I
S
Y
S
S
Q
E
E
I
Cat
Felis silvestris
Mouse
Mus musculus
NP_659084
2143
242053
S406
H
L
F
E
E
Y
I
S
Y
S
S
Q
E
E
T
Rat
Rattus norvegicus
NP_001101888
2143
241191
S406
R
L
F
E
E
Y
I
S
Y
S
S
Q
E
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422958
2155
244590
S406
K
F
L
E
E
F
V
S
Y
S
T
E
I
E
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q7SY48
2159
242032
G408
L
E
E
Y
V
V
C
G
N
E
L
P
S
D
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM75
2096
237201
M407
A
I
D
A
P
E
P
M
E
T
N
S
N
E
D
Honey Bee
Apis mellifera
XP_393800
2028
231830
A403
S
S
D
V
S
N
E
A
K
D
F
L
V
K
L
Nematode Worm
Caenorhab. elegans
Q23495
1650
185210
I95
N
E
E
L
N
K
Q
I
E
K
L
L
L
E
L
Sea Urchin
Strong. purpuratus
XP_794611
1635
181917
R80
E
A
S
K
S
L
E
R
S
I
E
N
R
E
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8Z4
2001
224001
R405
Y
Q
K
N
S
D
F
R
S
S
T
S
G
S
W
Baker's Yeast
Sacchar. cerevisiae
P42945
1769
200063
T214
T
N
Q
L
L
F
T
T
C
C
F
I
N
V
V
Red Bread Mold
Neurospora crassa
Q7RZM8
1788
196873
G233
L
L
D
K
Y
R
S
G
R
R
S
I
Q
I
E
Conservation
Percent
Protein Identity:
100
99.5
N.A.
89.7
N.A.
83.8
84.9
N.A.
N.A.
65.5
N.A.
54.5
N.A.
28.6
30.5
21.1
24.4
Protein Similarity:
100
99.8
N.A.
95
N.A.
92.1
92.7
N.A.
N.A.
80.5
N.A.
73
N.A.
49.4
50.8
38.9
43.2
P-Site Identity:
100
100
N.A.
93.3
N.A.
86.6
86.6
N.A.
N.A.
40
N.A.
6.6
N.A.
6.6
0
6.6
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
86.6
86.6
N.A.
N.A.
66.6
N.A.
13.3
N.A.
26.6
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.4
21.2
23
Protein Similarity:
N.A.
N.A.
N.A.
43.4
40.2
42.2
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
20
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
8
0
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
8
8
0
0
0
0
0
% C
% Asp:
0
0
22
0
0
8
0
0
0
8
0
0
0
8
8
% D
% Glu:
8
15
15
43
43
8
15
0
15
8
8
8
36
65
8
% E
% Phe:
0
8
36
0
0
15
8
0
0
0
15
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
15
0
0
0
0
8
0
8
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
36
8
0
8
0
15
8
8
15
% I
% Lys:
8
0
8
15
0
8
0
0
8
8
0
0
0
8
0
% K
% Leu:
36
43
8
15
8
8
0
0
0
0
15
15
8
0
15
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
15
% M
% Asn:
8
8
0
8
8
8
0
0
8
0
8
8
15
0
0
% N
% Pro:
0
0
0
0
8
0
8
0
0
0
0
8
0
0
0
% P
% Gln:
0
8
8
0
0
0
8
0
0
0
0
36
8
0
0
% Q
% Arg:
8
0
0
0
0
8
0
15
8
8
0
0
8
0
0
% R
% Ser:
8
8
8
0
22
0
8
43
15
50
43
15
8
8
8
% S
% Thr:
8
0
0
0
0
0
8
8
0
8
15
0
0
0
15
% T
% Val:
0
0
0
8
8
8
8
0
0
0
0
0
8
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
8
0
0
8
8
36
0
0
43
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _